MK-677 (Ibutamoren) – Review and Benefits

What is MK-677?

Ibutamoren Mesylate or MK-677 can be found under many names, such as:

– MK-677, 0677
– L-163, 191 ; L-163191
– The Former tentative brand name “Orantrope”
– Rarely “Crescendo”
– More commonly known as “Nutrobal”

MK-677 is widely spoken of on the internet forums, it’s actually more discussed there rather than in actual clinical research. MK-677 is very potent, a long-acting, non-peptide agonist of the ghrelin receptor, and a growth hormone secretagogue which mimics the growth hormone which then simulates the action of the endogenous hormone ghrelin. MK-677 is mostly used by bodybuilders and athletes because of its muscle-building properties and since it is an over the counter drug it can be used by those wishing to increase their growth hormone levels.

MK-677 promotes the secretion of the growth hormone (GH) and increases production of insulin-like growth factor 1. As MK-677 increases the growth hormone levels and mimics the action of the hormone ghrelin which then binds to one of the ghrelin receptors (GHSR) in the brain. Then the brain is stimulated to create the growth hormone because of the activated GHSR. Ghrelin receptors are located in the areas of the brain that command a wide range of functions, like appetite, mood, memory, and cognitive functions. MK-677 has been clinically proven to affect appetite by increasing it and is unclear for any other functions. MK-677 has originally been created for usage and managing health problems, like osteoporosis, obesity, muscle loss.

How does MK-677 work?

Nutrobal is a known S.A.R.M. MK 677 is a selective androgen receptor modulator or short for SARM.

The biggest benefit of MK-677 is that it increases the level of the growth hormone, which is essential to muscle growth, but without the risk of increasing the level of cortisol.

Cortisol is a steroid hormone, which belongs to the glucocorticoid class of hormones. It is responsible for a variety of harmful changes such as:

  • Immune system suppression
  • Decreased healing of wounds
  • Learning and memory impairments
  • Producing high levels of glucose over the long-term which leads to high blood sugar levels

Benefits of MK-677

MK-677 offers a wide range of health benefits. Promotes muscle growth and improves body shape (since it is a GH).

Taking MK-677 once daily will show anabolic benefits, such as a promotion of increasing in lean body mass.
As previously mentioned, it wasn’t short that bodybuilders started using this supplement, since the results give an increase in muscle mass in individuals who use MK-677.

There have been results from multiple studies that demonstrate both the muscle-building and fat reducing as a benefit of using MK-677. What is less known about this supplement is that it improves your body’s nitrogen balance. There has been a study which proves giving a low-calorie diet, and growth hormone treatment results in the vastly increased fat-loss, produces anabolic effects, and vastly improves the production of the growth hormone. So, rather than reducing the quantity of fat keep in your body directly, the merchandise works by increasing your craving and increasing the deposition of calories into your muscles, it is said it effectively increases the levels of IGF-1 by around thirty-eight to eighty-nine percent, which then increases your muscle mass and eventually improves the shape of your body.

Increasing bone strength

As many studies have shown, MK-677 is effective and can be used in increasing of bone mineral density and osteoporosis, and is known in increasing bone strength. There have been some ongoing studies to prove that MK-677 can be used in treating hip fractures in senior adults, and the results so far have been proving worthy. It usually takes periods of over a year to experience a vital increase in bone density as a result of somatotrophic hormone treatments, but that is dependent on the body itself and some other factors.

A research group from Sweden gathered twenty-four obese men, with age ranging from 19-49 that had no serious health issues documented, and observed the effects of the orally active growth hormone MK-677 on markers of bone metabolism.

After fifty-six days or eight weeks, the scientists concluded that the male obese subjects had improvements in markers both for bone resorption and formation of bones. The group of researches decided that if there were studies that were long-term they would be guaranteed to find out if taking MK-677 in a long-term would be crucial to increasing bone mass. In a study for post-menopausal women, researchers gathered 292 women and proved that MK-677 increased bone mineral density, which then prevents osteoporosis and increases bone strength.

Increased Endurance

As many bodybuilders and non-professional athletes have started using this supplement, it meant its name would be widely recognized, and the reason behind it is because MK-677 not only gives you bone strength or bone density, it can vastly increase your strength and your endurance, as well as your energy levels. So if you’re in search of some product that can help you in a lot of different matters MK-677 is just the right thing for you.

Positive effects on sleeping

Although it’s not very clear how, or to what extent, it is known that growth hormone has played a role in the regulations of sleep patterns for a long time now. A study by some researches in Brussels, Belgium has stated that there was a fifty percent increase stage four sleep and twenty percent increase in REM sleep in the younger patients when compared to subjects that were given placebos. So these findings proved that MK-677 can vastly increase your sleep quality while at the same time controlling your hormone levels and correcting the decline. Many critics have argued that results from one study are not enough of a proof of MK-667’s role in the improvement of sleep quality, but researchers say otherwise.

Positive effect on cognitive functions

Many individuals use this SARM (MK-677) as a nootropic because of its relation to the ghrelin receptor (GHSR) and claim that it does have nootropic effects. There aren’t many proofs of MK-677 being a direct nootropic and how it would affect the human’s cognitive function, but in correlation, there can be two methods that explain how MK-677 can provide the improvement in cognitive functions. The first method would be where MK-677 can impact cognitive function through IGF-1, a hormone that is increased in individuals through the usage of MK-677, and affect the individual’s capacity for memory and learning.

The second method by which MK-677 could affect cognitive functions could be through the improvement of the quality of sleeping and giving an increase in the duration of REM sleep cycles. As one study, conducted in North Wales, Pennsylvania, considered the connection of low IGF-1 to Alzheimer’s disease. So the researchers gathered 563 patients with mild to moderate Alzheimer’s and placed them in either an experimental group where they gave 25mgs of Ibutamoren daily or a placebo one. The testing lasted for a period of 12 months but was unable to confirm that Alzheimer’s was being slowed through the usage of MK-677.

Other ways MK-677 can help you

  • Heals old injuries
  • Tightens loose skin
  • Heals bones, ligaments, and tendons
  • Increased oxidation of fats
  • Combats aging
  • And a possible cure for a hangover

Side effects of using MK-677

This supplement is vastly considered safe and can be used by a wide range of people, although there have been some reports about some small and not scary side effects.
The side effect mostly connected to MK-677 would be the increased appetite.
Some mild cases of edema and muscle pain, on some occasions people have experienced diabetic complications like higher fasting blood levels and a decrease in the effect of insulin. It is highly recommended users of MK-677 keep an eye on their glucose which means limit their sugar intake and watch on their insulin levels.

People that are TH1 dominant are advised to avoid the supplement, as it is known that Ibutamoren has the ability to simulate the immune system. The known drug interactions for Ibutamoren aren’t well-known at this point, as additional analysis on the matter is in progress. It is usually considered to be safe to supplement with Ibutamoren even though you’re taking different medications or supplements, however, it’s necessary to remain conscious of your own body’s reactions once combining these substances.

It is advisory to be on alert that if you’re a diabetic person, or you are with a predisposition for the disease, diabetics that are currently taking insulin might encounter a different kind of problems. The potential for a cycle that might result from elevated aldohexose(sugar) levels resulting in a larger want for insulin, besides a constantly-increasing endocrine resistance, might lead to an especially dangerous set of circumstances.


All dosages have been considered safe, but it’s always a nice idea to start from a lower dosage (5mg) and steadily increase it to the highest recommended (25mg). It is a personal choice for the amount of daily intake of MK-677.